Chromium Picolinate is, besides chromium polynicotinate, a nutritional supplement designed to avoid or treat chromium deficiency. Insulin requires some modest levels of chromium in order to utilize glucose in healthy individuals. There is no record of chromium deficiency occurrences in regular population, only prolonged dieters in clinically observed and controlled obesity reduction treatments have registered any. Clinical trials have suggested that chromium picolinate may have antidepressant qualities, when applied to patients with atypical depression. Further observation signaled a reduction in carbohydrate cravings and seemed to regulate appetite. These results led to the incorporation of chromium picolinate into supplements for athletes who are working on body development and are looking to lose weight. It has been also observed that chromium picolinate is able to boost the blood levels of insulin for a limited time.

Fucoxanthin is an organic pigment common to photosynthetic organisms. Carotenoids, to which fucoxanthins belong, are deemed precursors to Vitamin A and can act as antioxidants as well. In Japan, at the Hokkaido University, a study was conducted on mice that has shown fucoxanthin to promote fat burning within fat cells. Brown algae is known as the best supplier of fucoxanthin, a fixture in the Asian cuisine. The fat burning ability of fucoxanthin has not been verified in clinical trials on humans, but many weight loss products nowadays have it as a major ingredient. It is very popular in body building circles, where it is deemed not only to help burn excess stored fat, but increase energy levels as well. There are no side effects of fucoxanthin known to exist.

Garcinia Cambogia is helpful for weight loss as it suppresses accumulation of body fats. It promotes fat oxidation, increases serotonin release and its availability in brain, normalizes lipid profiles and reduces serum leptin levels in overweight people. Garcinia cambogia extract improves mucosal defensive mechanisms in the stomach and, so, is a good protective agent against gastric ulcers. It reduces both the volume and acidity of gastric juice. It acts as an appetite suppressant and also enhances metabolism. Garcinia cambogia can be helpful for people who attempt to have a low carb diet. It helps improve energy levels and strengthen the immune system. Garcinia cambogia extract can increase mucosal defense means in stomach, thus helping with gastric ulcers. It can decrease stomach acidity, and increase defensive properties on gastric juices.

Gymnema Sylvestre has been naturally found in southern and in central India and here they are utilised in traditional medicines for about 2000 years. In the historical Indian text, this is called as gurmar, where this word means sugar destroyer that provides an indication that these are used in the medicine. This is utilised for reducing the glucose absorption which takes place inside your body and even declines the foods sweetness, this could be best suited for those people who want to reduce their weight as well as for those who wants to decline the sugar level which is present in the blood. This is also utilised in Ayurvedic medicine.

Hoodia Gordonii, which although popular, has no published randomized controlled trials in humans to show hoodia is safe or effective in pill form. One study published in the September 2004 issue of Brain Research found that injections of p57 (The Active ingredient in Raw, Fresh Cut Hoodia, not dried) into the appetite center of rat brains resulted in altered levels of ATP, an energy molecule that may affect hunger. The animals receiving the P57 injections also ate less than rats that received placebo injections. However, this was an animal study and INJECTIONS IN THE BRAIN are very different from oral consumption, so it cannot be used to show that oral hoodia can suppress appetite in humans. Hoodia Gordonii is a succulent (a cactus of the aloe family) found in the Kalahari desert of South Africa. Most Hoodia Gordonii products contain very little, if any of the active ingredient needed to suppress hunger. Real Hoodia is very rare and is even an endangered plant. Most importantly, Hoodia has only demonstrated any effect in fresh, raw pieces of the plant. The effectiveness of powdered Hoodia has yet to be shown and may actually increase hunger. It's main use is as a cheap alternative to the more expensive weight loss herbs, which are the only alternative left after the banning of ephedra. Most supplement manufacturers can not use the more expensive weight loss herbs because it will result in a product that would be too expensive to compete with other more popular inexpensive diet supplements.

Resveratrol (trans-resveratrol) is a phytoalexin produced naturally by several plants when they are attack by pathogens. It is also produced synthetically and sold as a supplement. Resveratrol is a polyphenolic phytoalexin, its chemical formula is C14H12O3 and Mol. Mass is 228.24 g mol-1. Research shows that Resveratol has anti-inflammatory and anti-cancer effects. Some studies also reported that it can lower elevated blood sugar levels; however, in majority of these experiments mice were the test subjects and its effects are yet to be replicated in humans. Experiments on nematode worms, fruit flies and short-lived fish have shown that Resveratrol can increase life span, but it did not increase the life span of mice.