Chromium Picolinate is, besides chromium polynicotinate, a nutritional supplement designed to avoid or treat chromium deficiency. Insulin requires some modest levels of chromium in order to utilize glucose in healthy individuals. There is no record of chromium deficiency occurrences in regular population, only prolonged dieters in clinically observed and controlled obesity reduction treatments have registered any. Clinical trials have suggested that chromium picolinate may have antidepressant qualities, when applied to patients with atypical depression. Further observation signaled a reduction in carbohydrate cravings and seemed to regulate appetite. These results led to the incorporation of chromium picolinate into supplements for athletes who are working on body development and are looking to lose weight. It has been also observed that chromium picolinate is able to boost the blood levels of insulin for a limited time.

Fucoxanthin is an organic pigment common to photosynthetic organisms. Carotenoids, to which fucoxanthins belong, are deemed precursors to Vitamin A and can act as antioxidants as well. In Japan, at the Hokkaido University, a study was conducted on mice that has shown fucoxanthin to promote fat burning within fat cells. Brown algae is known as the best supplier of fucoxanthin, a fixture in the Asian cuisine. The fat burning ability of fucoxanthin has not been verified in clinical trials on humans, but many weight loss products nowadays have it as a major ingredient. It is very popular in body building circles, where it is deemed not only to help burn excess stored fat, but increase energy levels as well. There are no side effects of fucoxanthin known to exist.

Garcinia Cambogia is helpful for weight loss as it suppresses accumulation of body fats. It promotes fat oxidation, increases serotonin release and its availability in brain, normalizes lipid profiles and reduces serum leptin levels in overweight people. Garcinia cambogia extract improves mucosal defensive mechanisms in the stomach and, so, is a good protective agent against gastric ulcers. It reduces both the volume and acidity of gastric juice. It acts as an appetite suppressant and also enhances metabolism. Garcinia cambogia can be helpful for people who attempt to have a low carb diet. It helps improve energy levels and strengthen the immune system. Garcinia cambogia extract can increase mucosal defense means in stomach, thus helping with gastric ulcers. It can decrease stomach acidity, and increase defensive properties on gastric juices.

Gymnema Sylvestre, also known as Gurmar and Meshashringi, or 'sugar destroyer'. Gymnema Sylvestre leaves have a blood sugar lowering effect. The leaf extracts also contain gymnemic acid which inhibits hyperglycemia and also acts as a cardiovascular stimulant. Gymnema Sylvestre is commonly used to remove the taste of sugar, therefor reducing cravings for sweets.

Hoodia Gordonii is a succulent from the family Apocynaceae. It is a native plant of South Africa and Namibia. It is also commonly known as Bushman's Hat and Queen of the Namib. In appearance Hoodia gordonii is similar to cactus, but it has large tan colored flowers with strong smell. It has been used in traditional medicine for weight loss since a long time. It is increasingly being used in modern weight loss supplements because research has shown its appetite suppressant effects. Hoodia gordonii is not currently on the list of endangered species, but it is feared to become endangered if its excessive foraging and trade is not controlled.

Resveratrol (trans-resveratrol) is a phytoalexin produced naturally by several plants when they are attack by pathogens. It is also produced synthetically and sold as a supplement. Resveratrol is a polyphenolic phytoalexin, its chemical formula is C14H12O3 and Mol. Mass is 228.24 g mol-1. Research shows that Resveratol has anti-inflammatory and anti-cancer effects. Some studies also reported that it can lower elevated blood sugar levels; however, in majority of these experiments mice were the test subjects and its effects are yet to be replicated in humans. Experiments on nematode worms, fruit flies and short-lived fish have shown that Resveratrol can increase life span, but it did not increase the life span of mice.